According to current knowledge, yes. If the gas cloud is too massive, the pressure of the radiation prevents the collapse and the star formation.
The article Stars Have a Size Limit by Michael Schirber, it's about 150 Solar Masses. However, there's the Pistol Star, which is speculated to be 200 SM.
In the article 'Das wechselhafte Leben der Sterne' by Ralf Launhard (Spektrum 8/2013) there's a diagram with information that when the mass is over 100 SM, the star can't form because of radiation pressure. The exact value of the limit is not speculated in the article.