Even "round" galaxies look different from stars
cphyc's answers the question excellently: Spectroscopy is the answer, although since — as explained below — galaxies are not point sources, the morphology of stars and galaxies is also different: even elliptical galaxies observed along one of their axes look different from stars. Although both are round, the way that their light falls off radially is different; stars' light decrease roughly as a normal distribution from the center and out (with some extra profile folded in which depends on the instrument), while the surface brightness profile of galaxies decrease in a somewhat more complicated fashion (e.g. a Sérsic profile).
Can galaxies be point sources?
Wrt. the fraction of galaxies that are point source, the answer is virtually none. Galaxies can almost always be resolved although, as cphyc also correctly says, not with any instrument. Radio and gamma-ray telescopes have very poor resolution, and at these wavelengths the sources usually cannot be resolved unless they're relatively nearby. But at optical wavelengths, as well as UV and IR, telescopes like the Hubble Space Telescope and even good ground-based telescopes can resolve ~all galaxies, unless they're so small that they're too dim to be seen anyway.
Angular diameter in an expanding Universe
The reason is a rather peculiar feature of the expanding Universe: A galaxy will look smaller and smaller, the farther away it is (as expected from everyday life), but only out to a certain distance, after which they will appear larger and larger. Why is this so? Because light moves with a finite speed, we observe galaxies as they were in the past — the more distant, the longer time ago. And since in an expanding Universe, "long time ago" also means closer, the angle that a galaxy spans on the sky is the angle that it spanned when it emitted the light, not the angle it spans today. That is, very distant galaxies emitted the light we see today when they were so close that they spanned a large angle.
The exact relation between distance and the solid angle of a galaxy depends on the cosmology (i.e. the values of density parameters, Hubble constant, etc.). For the latest Planck measurements (2015), a galaxy that is 1 kpc (~3000 lightyears) across — which would be considered a small galaxy — spans an angle given by this figure:
You'll see that galaxies look smaller and smaller the farther there are away, until at a distance of roughly 15 billion lightyears, after which they look larger again. The most distant galaxy observed, GN-z11, is so far away that its light was emitted less than half a billion years after the Big Bang. With a radius of $0.6\pm0.3\,\mathrm{kpc}$ (Oesch et al. 2016) it still spans 0.15 arcsec, which is resolvable by HST.
Decreasing surface brightness
Unfortunately, this effect also makes distant galaxies more difficult to detect. A galaxy only emits so much light, so distributing its light over, say, twice the angular diameter, makes it four times less bright.
Thus, the problem of observing very distant galaxies is not that they're small, but that they're dim.