I presume what you mean is how does the plane of the orbit compare to the equatorial rotation plane of the star?
The answer is, you can sort of estimate this, by using something called the Rossiter-McLaughlin effect (see also Rossiter 1924; McLaughlin 1924).
You can find plenty of information on the web - I'll add a couple of links when I have a moment - but to summarise:
The rotation of a star broadens its spectral absorption lines. The hemisphere coming towards us emits light that is is blue shifted, the hemisphere receding is redshifted. If we now take a transiting planet, during the eclipse it crosses the disc of the star and obscures regions that are blue or red shifted by various amounts.
Now what you do is measure the line-of-sight velocity of the star. During the transit you would not expect this to vary due to the "Doppler wobble" caused by the exoplanet, except that if the planet obscures a blue shifted portion of the stellar disc, the net spectral absorption line that remains shifts to the red, and vice-versa. The pattern of red, then blue shift (or vice versa) as the transit progresses is known as the Rossiter-Mclaughlin effect.
A schematic showing how the Rossiter-McLaughlin effect works and how a different transit geometry with respect to the rotation axis of the star leads to a different line-of-sight-velocity signature in the spectral lines of the star. (Image credit: Subaru Telescope, National Observatories of Japan.)
If the planet orbits in the same plane and in the same direction as the stellar rotation (as the planets in our solar system nearly do), then the blue shifted limb of the parent star is obscured first, followed by an equal amount of redshift as the planets moves to obscure the receding stellar limb (see image above, left). Thus the stellar absorption lines show a redshift followed by a symmetric blueshift. If the planet was retrograde it would be symmetric but occur in the opposite order. A Polar orbit would show no RM effect. Inclined orbits would have an asymmetric RM effect - ie perhaps more blueshift than redshift (see image above, right).
The RM effect cannot give an exact orientation, it gives the projected angle between orbital and rotation axes on the plane of the sky. Nevertheless, that is sufficient for us to know that a lot of the transiting exoplanets have highly misaligned orbital and stellar rotation axes.