I don't think it means anything special. Take, for example, the claim at Wikipedia
An interstellar cloud is generally an accumulation of gas, plasma, and
dust in our and other galaxies. Put differently, an interstellar cloud
is a denser-than-average region of the interstellar medium, (ISM), the
matter and radiation that exists in the space between the star systems
in a galaxy. Depending on the density, size, and temperature of a
given cloud, its hydrogen can be neutral, making an H I region;
ionized, or plasma making it an H II region; or molecular, which are
referred to simply as molecular clouds, or sometimetimes dense clouds.
Neutral and ionized clouds are sometimes also called diffuse clouds.
An interstellar cloud is formed by the gas and dust particles from a
red giant in its later life.
As well as another statement
In all phases, the interstellar medium is extremely tenuous by
terrestrial standards. In cool, dense regions of the ISM, matter is
primarily in molecular form, and reaches number densities of $10^6$
molecules per $cm^3$ (1 million molecules per cm3). In hot, diffuse
regions of the ISM, matter is primarily ionized, and the density may
be as low as $10^{−4}$ ions per $cm^3$. Compare this with a number density of
roughly $10^{19}$ molecules per cm3 for air at sea level, and $10^{10}$
molecules per $cm^3$ (10 billion molecules per $cm^3$) for a laboratory
high-vacuum chamber.