It's not possible to obtain a star that large without accretion, however you can still consider it to be a "single star" because it's not bound to other stars. Many people think that there is an upper limit on the mass of a star, but it is based on outdated stellar evolution models and physics, or is only relevant for present galaxies and not for the early Universe environment. This has been known for at least a decade.
IT is true that the most massive stars that we have observed to date are only up to $\sim 250$ M$_{\odot}$, but those are late-stage stars, usually Wolf-Rayet stars, that have long evolved off the main sequence and lost their envelopes, so they are irrelevant for the question posed by the OP which concerns the progenitors of supermassive black holes.
Stars that are likely seeds for supermassive black holes have been dubbed "supermassive stars," unsurprisingly. Although it is still uncertain exactly how such supermassive stars accrete mass, recent studies suggest that these stars would be slowly rotating due to the large amount of angular momentum needed to be extracted in order for the gas cloud to collapse gravitationally. These supermassive stars at high redshift might be detectable by the James Webb Space telescope.
Here is a review about the properties of these supermassive stars. The role of metallicity is important, as high metallicity stars will very likely not be massive enough to form a supermassive black hole, but rather a stellar mass black hole. Nevertheless, the conditions of the early universe are likely to not be rich in metals, so it is not impossible to expect that a Population III supermassive star could form into a seed of a supermassive black hole, i.e. a black hole of mass $\sim 10^4 - 10^6$ M$_{\odot}$, and then accretion of nearby gas over cosmic time brings the black hole's mass to much larger values, such as observed for Ton 618. However, keep in mind that the existence of supermassive stars is uncertain so this should be taken with a grain of salt, but it is within the realm of current possibility, theoretically speaking, which ought to be sufficient for your video game.