The current largest digital CCD is the Large Synoptic Sky Survey (LSST) camera, which has a whopping 3.2 gigapixel resolution. The previous largest features on the Panoramic Survey Telescope & Rapid Response System (Pan-STARRS), and has a resolution of ~1.4 gigapixels.[1]
Based on the spec sheet provided by the Vera Rubin Observatory, the LSST camera has a resolution of roughly 0.2 arcseconds per 10 $\mu$m pixel. It is about 5 feet wide and weighs over 6000 lbs.[2]
Cameras of this size often have pointing, calibration and recording issues. These sources of error are usually extremely well understood, but it's still interesting to see. Pan-STARRS has a detailed list on their data site[3]. These issues include:
- Randomly missing data that gets filled in later
- Pointing errors related to astrometric positions of their targets
- Registration issues near the celestial pole resulting in poor photometry